杨贝(上海科技大学生命科学与技术学院助理教授)
杨贝
上海科技大学生命科学与技术学院助理教授
杨贝,女,博士,毕业于中国科学院,现任上海科技大学生命科学与技术学院助理教授。
研究于感染性疾病与遗传性罕见病。
中文名 | 杨贝 |
毕业院校 | 中国科学院 |
学位/学历 | 博士 |
职业 | 教师 |
职务 | 上海科技大学生命科学与技术学院助理教授 |
人物经历
教育经历
2000.09—2004.06,武汉大学生物学基地班,学士
2004.09—2010.07,中国科学院上海生物化学与细胞生物学研究所,博士
工作经历
2010.08—2013.06,美国国立健康研究院,博士后
2013.07—2015.07,美国加州大学伯克利分校,博士后
2015.11—2020.09,上海科技大学免疫化学研究所,副研究员
2020.10—至今,上海科技大学生命科学与技术学院、免疫化学研究所,助理教授(TENURE-TRACK)
主要成就
科研成就
论文
1. Wang, Lijie*; Xue, Wei*; Zhang, Hongxia*; Gao, Runze*; Qiu, Houyuan*; Wei, Jia; Zhou, Lina; Lei, Yun-Ni; Wu, Xiaocheng; Li, Xiao; Liu, Chengfang; Wu, Jing; Chen, Qiubing; Ma, Hanhui; Huang, Xingxu; Cai, Cheguo; Zhang, Ying; Yang, Bei#; Yin, Hao#; Yang, Li#; Chen, Jia#.Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations.NATURE CELL BIOLOGY. May 2021. 23(5):552-563.
2. Xiaojie Shi*; Yue Wan*; Nan Wang*; Jiangchao Xiang*; Tao Wang; Xiaofeng Yang; Ju Wang; Xuxue Dong; Liang Dong; Lei Yan; Yu Li; Lili Liu; Shinchen Hou; Zhenwei Zhong; Ian A. Wilson; Bei Yang; Guang Yang#; Richard A. Lerner#.Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms.NATURE COMMUNICATIONS. 2021.
3. Meng, Bing*; Lan, Keke; Xie, Jia; Lerner, Richard A.; Wilson, Ian A.#; Yang, Bei#.Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 16 Jun 2020. 117(24):13499-13508.
4. Wang, Xiao*; Ding, Chengfeng*; Yu, Wenxia*; Wang, Ying*; He, Siting*; Yang, Bei*; Xiong, Yi-Chun; Wei, Jia; Li, Jifang; Liang, Jiayi; Lu, Zongyang; Zhu, Wei; Wu, Jing; Zhou, Zhi; Huang, Xingxu; Liu, Zhen#; Yang, Li#; Chen, Jia#.Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response.CELL REPORTS. Jun 2020. 31(9).
5. Cui, Yan-ru*; Wang, Shao-jie*; Chen, Jun; Li, Jie; Chen, Wenzhang; Wang, Shuyue; Meng, Bing; Zhu, Wei; Zhang, Zhuhong; Yang, Bei; Jiang, Biao; Yang, Guang; Ma, Peixiang#; Liu, Jia#.Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides.GENOME BIOLOGY. 26 Feb 2020. 21(1).
6. Xu, Juncao*; Cui, Kaijie*; Shen, Liqiang; Shi, Jing; Li, Lingting; You, Linlin; Fang, Chengli; Zhao, Guoping#; Feng, Yu#; Yang, Bei#; Zhang, Yu#.Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor.ELIFE. 17 Dec 2019. 8.
7. Yang, Li#*; Yang, Bei#; Chen, Jia#.One Prime for All Editing.CELL. Dec 2019. 179(7):1448-1450.
8. Zhao, Quanju*; Ren, Chaowei*; Liu, Linyi*; Chen, Jinju; Shao, Yubao; Sun, Ning; Sun, Renhong; Kong, Ying; Ding, Xinyu; Zhang, Xianfang; Xu, Youwei; Yang, Bei; Yin, Qianqian#; Yang, Xiaobao#; Jiang, Biao#.Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.JOURNAL OF MEDICINAL CHEMISTRY. 24 Oct 2019. 62(20):9281-9298.
9. Wang, Ying*; Gao, Runze*; Wu, Jing*; Xiong, Yi-Chun; Wei, Jia; Zhang, Sipin; Yang, Bei; Chen, Jia#; Yang, Li#.Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs.GENOME BIOLOGY. Oct 2019. 20(1).
10. Chen, Jia#*; Yang, Bei#; Yang, Li#.To BE or not to BE, that is the question.NATURE BIOTECHNOLOGY. May 2019. 37(5):520-521.
11. Xia, Shuai*; Yan, Lei*; Xu, Wei*; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.#; Jiang, Shibo#; Yang, Bei#; Lu, Lu#.A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.SCIENCE ADVANCES. Apr 2019. 5(4).
12. Yang, Bei#*; Yang, Li#; Chen, Jia#.Development and Application of Base Editors.CRISPR JOURNAL. Apr 2019. 2(2):91-104.
13. Wang, Xiao*; Li, Jianan*; Wang, Ying*; Yang, Bei*; Wei, Jia*; Wu, Jing; Wang, Ruixuan; Huang, Xingxu#; Chen, Jia#; Yang, Li#.Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion.NATURE BIOTECHNOLOGY. Oct 2018. 36(10):946-949.
14. Yan, Lei*; Meng, Bing; Xiang, Jiangchao; Wilson, Ian A.#; Yang, Bei#.Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution.ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. Sep 2018. 74:841-851.
15. Qiang, Min*; Dong, Xue*; Zha, Zhao; Zuo, Xiao-Kun; Song, Xing-Lei; Zhao, Lixia; Yuan, Chao; Huang, Chen; Tao, Pingdong; Hu, Qin; Li, Wei-Guang; Hu, Wanhui; Li, Jie; Nie, Yan; Buratto, Damiano; Zonta, Francesco; Ma, Peixiang; Yu, Zheng; Liu, Lili; Zhang, Yi; Yang, Bei; Xie, Jia; Xu, Tian-Le; Qu, Zhihu#; Yang, Guang#; Lerner, Richard A.#.Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 07 Aug 2018. 115(32):E7469-E7477.
16. Li, Xiaosa*; Wang, Ying*; Liu, Yajing*; Yang, Bei*; Wang, Xiao; Wei, Jia; Lu, Zongyang; Zhang, Yuxi; Wu, Jing; Huang, Xingxu#; Yang, Li#; Chen, Jia#.Base editing with a Cpf1-cytidine deaminase fusion.NATURE BIOTECHNOLOGY. Apr 2018. 36(4):324-327.
17. Lei, Liqun*; Chen, Hongquan*; Xue, Wei*; Yang, Bei*; Hu, Bian*; Wei, Jia; Wang, Lijie; Cui, Yiqiang; Li, Wei; Wang, Jianying; Yan, Lei; Shang, Wanjing; Gao, Jimin; Sha, Jiahao; Zhuang, Min; Huang, Xingxu; Shen, Bin#; Yang, Li#; Chen, Jia#.APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks.NATURE STRUCTURAL & MOLECULAR BIOLOGY. Jan 2018. 25(1):45-52.
18. Wang, Lijie*; Xue, Wei*; Yan, Lei*; Li, Xiaosa; Wei, Jia; Chen, Miaomiao; Wu, Jing; Yang, Bei#; Yang, Li#; Chen, Jia#.Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor.CELL RESEARCH. Oct 2017. 27(10):1289-1292.
19. Yang, Bei#*; Li, Xiaosa; Lei, Liqun; Chen, Jia#.APOBEC: From mutator to editor.JOURNAL OF GENETICS AND GENOMICS. Sep 2017. 44(9):423-437.
项目
1. 国家自然科学基金青年项目,国家自然科学基金委,项目负责人
2. 国家自然科学基金面上项目,国家自然科学基金委,项目负责人
3. 国家重点研发计划 ,中华人民共和国科技部,课题参与人员(非负责人)
4. 国家科技重大专项‘艾滋病疫苗研究’,中华人民共和国科技部,课题参与人员(非负责人)
荣誉表彰
2016年,浦江人才
参考资料
1.杨贝·上海科技大学